Description
Zolpidem (10 mg) is a non-benzodiazepine hypnotic medicine known as a “Z-drug” that is used to treat insomnia. It belongs to the class of medications known as central nervous system (CNS) depressants, which slow down the neurological system. It is specifically intended for the short-term treatment of sleep problems, particularly in people who have trouble falling asleep. Zolpidem will help you fall asleep quickly and stay asleep all night. Most of the time, sleep medication should only be taken for a short time, like one or two days, and not for more than one or two weeks.
This medicine works by reducing excessive brain activity, allowing the body to more quickly transition into sleep. In the UK, zolpidem is typically prescribed under medical supervision. It should be used with caution and only when recommended by a skilled medical professional.
Summary of Zolpidem (Zolpidem Tartrate)
| Type of drug | Nonbenzodiazepine (Z drugs) / Central Nervous System (CNS) depressants / Sleeping pill |
| Health conditions prescribed for | Insomnia (including primary insomnia and chronic insomnia) |
| Active Ingredients | Zolpidem tartrate |
| Available strengths | 10mg |
| Available as | Tablets, modified release tablets (Zolpidem MR / Ambien CR) |
| Possible side effects | Bitter/metallic taste in the mouth, dry mouth, feeling sleepy/tired the next day, headaches, feeling dizzy, nausea, vomiting, diarrhoea, back pain |
How Zolpidem Works
Zolpidem belongs to a class of medications known as non-benzodiazepine hypnotics. It has hypnotic, sedative, and anticonvulsant effects (helps with fits). It acts by attaching to the GABAA receptor chloride channel macromolecular complex (a chemical messenger), which lowers the activity of nerve cells in the brain and aids in sleep.
This action helps you fall asleep faster and get to sleep. Zolpidem doesn’t last as long as some other sleep medication, so it’s less likely to still be working the next day. Its focused mechanism makes it work well for people who have trouble falling asleep but not remaining asleep.
Benefits of Zolpidem 10mg
The benefits of Zolpidem 10mg are given as follows:
- It allows you to fall asleep faster
- Effective at treating sleep-onset insomnia
- Short-acting formulation
- Improves the sleep routine
- It is appropriate for short-term use
Who Can Use Zolpidem
Zolpidem should be taken exactly as prescribed by your medical professional. This medicine is generally given to the adults who are suffering with short-term insomnia (difficulty falling asleep). It may also be explored when sleep problems are caused by stress, anxiety, travel (like jet lag), or short-term changes in lifestyle. When non-pharmacological methods, like better sleep hygiene, have failed, this medication is usually advised.
Examination of a suitable person is done by a qualified medical professional, who will evaluate various factors which include medical history, current medications, and overall health status before starting the treatment. It is of utmost importance to ensure that this treatment is appropriate and safe for each specific patient.
Usage of Zolpidem 10mg
Zolpidem 10 mg is usually taken once a day as recommended by a medical professional before going to bed. This medicine is only taken if sleeping time is 7-8 hours (if possible) or a full night, as waking up earlier may enhance the chance of drowsiness or decreased alertness for the next morning. The medication is designed for short-term use (few days to a few weeks), which depends upon the health condition and response to treatment. Long-term uses of this medication are generally not advised by the medical professional for risk of dependence and decreased effectiveness over time. Alcohol intake is not allowed when you are under medication, as it may enhance sedative effects and increase the risk of side effects. Always follow medical recommendations given by your medication professional.
Who Should Avoid Zolpidem
The risk of taking a medication must be evaluated against the benefits it will provide. This is a decision that you and your doctor will make. The following should be considered while considering this medication:
- Allergies: Tell your medical professional if you’ve ever had an unusual or adverse reaction to this or any other medication. Also, notify your medical professional if you have any other allergies, such as to foods, colors, preservatives, or animals. For non-prescription products, carefully study the ingredients on the label or packaging.
- Pediatric: Zolpidem is not advised for children. Safety and efficacy have not been shown.
- Geriatric:As of yet, no relevant research has identified any particular problems related to older adults that would restrict zolpidem’s effectiveness in this demographic. However, compared to young adults, older people are more susceptible to the effects of this medication.
- Breastfeeding: There are no beneficial studies for women to determine baby danger when taking this medicine while breastfeeding. Before taking this drug while nursing, consider the potential advantages and hazards.
Safety and Side Effects
Zolpidem, like all medicines, can cause side effects in some people, but not everyone experiences them.
Common side effects
- A metallic or bitter taste in your mouth, or a dry mouth.
- Feeling sleepy or tired the following day
- Headaches
- Feeling dizzy
- Nausea or vomiting
- Diarrhoea
- Back pain
Serious side effects
Some people can experience serious side effects with zolpidem, which are listed below:
- Amnesia
- Hallucinations
- Fall over (if you are over the age of 65).
- Delusions
- Depression
Rare but serious side effects
- Sleepwalking
- Anaphylaxis
Zolpidem vs Zopiclone
Both are non-benzodiazepine hypnotic medicines and commonly known as ‘Z-drugs’, which are used to treat sleep disorders (insomnia). Some key differences between zolpidem and zopiclone are given below:
- Zolpidem is known for its rapid onset of action (it is effective for those who have difficulty falling asleep); on the other hand, the effects of Zopiclone last longer.
- Zolpidem has a short duration of action, which may reduce the risk of daytime drowsiness the following day in some cases; on the other hand, zopiclone is more suitable for those who struggle to sleep continuously throughout the night or whose sleep is frequently interrupted.
The type of insomnia being treated determines which of zopiclone and zolpidem is best. Depending on each person’s needs, a medical professional can assist in choosing the best course of action.
Sleep Hygiene Tips
Improvement in the sleep pattern can significantly increase the effectiveness of insomnia treatment. It is essential to maintain a sleeping schedule by going to bed and waking up in the proper time. Not drinking caffeine and other stimulants later in the day may help you sleep better. Limiting the screen time before going to bed will be helpful in relaxing, and a dark and quiet sleeping environment can also help you sleep better. Adding new hobbies to your lifestyle before going to sleep, which include reading books and meditation, can be helpful in improving sleeping quality. According to various research, in the management of insomnia, changing lifestyle and proper medication are highly recommended by medical professionals.
FAQs
Q1: How fast does zolpidem work?
The zolpidem starts working within 15-30 minutes after intake. This medicine shows quick effects, so it is recommended before going to bed.
Q2: Is zolpidem safe to take every night?
Usually, medical professionals only provide zolpidem for a short time. You should only take it as advised by a medical professional and not use it all the time without medical guidance.
Q3: Can you become addicted to zolpidem?
If you use Zolpidem for a long time or don’t follow the directions, it can become habit-forming. That’s why it’s best to use it for a limited time and only with a doctor’s help.
Q4: What distinguishes zopiclone from zolpidem?
Zolpidem works well for initiating sleep because it operates fast and lasts less time. Because it lasts longer, zopiclone is frequently used to keep people asleep all night.
Disclaimer:
This information is not intended to be medical advice; it is merely for informational purposes. In the UK, zolpidem is a prescription-only medication that should only be taken under the guidance of a licensed medical practitioner. Before beginning any treatment, always speak with your medical professional
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Author & Medical Reviewer
Written by:
Dr. Ritika Joshi, MSc, PhD
Medical Content Writer
References:
- Zolpidem: medicine used for sleeping problems (insomnia) – NHS
- Zolpidem – Patient Information Leaflets – (emc)
- nhs.uk. 2021. Zolpidem: a sleeping pill used to treat insomnia. [online] Available at: https://www.nhs.uk/medicines/zolpidem/ [Accessed 20 September 2021].
- NICE-The National Institute for Health, Excellence C. BNF: British national formulary – NICE. [cited 2021 Sep 20]; Available from: https://bnf.nice.org.uk/drug/zolpidem-tartrate.html
- British National Formulary (BNF) A-Z list of drugs
- electronic medicines compendium (emc)
- Medicines and Healthcare products Regulatory Agency (MHRA) product search






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